The Chemistry Department Presents: Combining Theory and Experience to Develop Selective C-C Bond Formations via Open-Shell Intermediates

Presented by Dr. Osvaldo Gutierrez, Assistant Professor, University of Maryland

Guest Speaker Dr. Osvaldo Gutierrez, Associate Professor University of Maryland
Dr. Osvaldo Gutierrez, Associate Professor, University of Maryland

Despite advances in high-throughput screening methods leading to a surge in the discovery of catalytic reactions, our knowledge of the molecular-level interactions in the rate- and selectivity-determining steps of catalytic reactions, especially those involving highly unstable and reactive open-shell intermediates, is rudimentary. These knowledge gaps prevent control, suppression or enhancement, of competing reaction channels that can drive development of unprecedented catalytic reactions. In this talk, Dr. Gutierrez will focus on our use of high-level quantum mechanical calculations, rigorously calibrated against experimental data, to interrogate the mechanisms and to guide the development of new catalysts and reagents for currently sluggish or unselective reactions. In particular, he will focus on our use of combined experimental and computational tools to understand and develop new (asymmetric) iron-catalyzed radical cascade/cross-coupling reactions.

Refreshments will be served at 1:45 p.m.

Speaker Biography

Dr. Osvaldo Gutierrez was born in Mexico and raised in Sacramento, California. He attended Sacramento City College and transferred to UCLA in 2006 where he worked as an undergraduate at the laboratories of Prof. Houk. He obtained his BS/MS in 2009 and completed his PhD in 2012 (UC Davis) under the guidance of Prof. Tantillo. From 2012-2016 he worked as a postdoc with Prof. Kozlowski at the University of Pennsylvania where he used computational and experimental tools to study transition metal-catalyzed processes. He is now at the University of Maryland College Park where his research combines computational and experimental approaches to advance our understanding of iron- and photo-catalyzed reaction mechanisms. 

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