Featuring Dr. Lyle Isaacs, Professor of Chemistry, University of Maryland
The Department of Chemistry Presents, via In Person and Online Zoom Presentation: Lyle Issacs, PhD, Professor of Chemistry, University of Maryland
In this talk I will present our recent work on the preparation and use of macrocyclic and acyclic CB[n] (1 and 2) in biologically relevant applications. For example, I will discuss the use of acyclic CB[n] as a solubilizing excipient for insoluble drugs, as a reversal agent for neuromuscular block as well as hyperlocomotion induced by drugs of abuse (e.g. methamphetamine), and our recent discovery of ultrahigh affinity sulfated pillararenes.